Preventive medication to significantly reduce your risk of heart attack or stroke

What is the Polypill Prevention Programme?

The Polypill Prevention Programme includes a daily preventive medication consisting of carefully selected medicines combined at the right doses to have a major impact on preventing heart attacks and strokes with minimal risk of side effects. Read below to find out about the Polypill Prevention Programme and see our page about How it works.

The medicines in the Polypill Prevention Programme are supplied as three tablets containing four pharmaceutical ingredients. Previously, these ingredients were supplied in a single pill to make the medication convenient to take. We intend that in the future the ingredients will again be supplied in a single pill

The medicines used in the Polypill formulation have been shown to reduce the risk of heart attack and stroke, but not all of them are licensed for the primary prevention of the disease. Their use is therefore “off-label”.

What's in the preventative medication offered?

The preventive medication provided as part of the Polypill Prevention Programme is designed for maximum effectiveness and minimum side effects. The medication contains the following:

Name                             Dose                    What is it?
Atorvastatin 20mg Atorvastatin is a common well trialled medication which decreases LDL cholesterol levels in the blood by 43% 1 at this dose
Hydrochlorothiazide and irbesartan are supplied in a single pill
Hydrochlorothiazide lowers the blood pressure and has been used for many years. To reduce the chance of side effects, half the standard dose is used.
Irbesartan is an angiotensin receptor blocking (ARB) drug which also reduces blood pressure and is prescribed at a low dose.
Amlodipine 5mg Amlodipine is a calcium channel blocking (CCB) drug which reduces blood pressure that has been widely used for many years and is prescribed at a low dose.

Free online consultation with our doctors

Our doctors are able to assess your suitability for joining the Polypill Prevention Programme through an online consultation. If suitable, you can then place an order via our secure website. An order will result in a prescription which allows our partner pharmacy to dispense your medication. If you would like to discuss the Polypill Prevention Programme with your GP first, please do so. We provide more information for other doctors here .

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Backed by leading institutions and experts

The Polypill Prevention Programme is a powerful example of preventive medicine. All the Polypill Prevention Programme medicines have been widely used to treat people with cardiovascular disease. The objective is to prevent these diseases from arising in the first place. By using the right combination of medicines, the risk of a heart attack and stroke can be reduced by two thirds. The basis for this strategy was set out in a series of papers and journals.

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